Best Nootropic Supplements of 2025 – Top Brain and Memory Enhancement Supplements

The objective of nootropics supplements is to increase cognitive abilities such as focus, memory, information processing, critical thinking, and language abilities.

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Sources

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[1] Suliman NA, Mat Taib CN, Mohd Moklas MA, Adenan MI, Hidayat Baharuldin MT, Basir R. Establishing Natural Nootropics: Recent Molecular Enhancement Influenced by Natural Nootropic. Evid Based Complement Alternat Med. 2016;2016:4391375. doi: 10.1155/2016/4391375. Epub 2016 Aug 30. PMID: 27656235; PMCID: PMC5021479.

[2] Malík M, Tlustoš P. Nootropics as Cognitive Enhancers: Types, Dosage and Side Effects of Smart Drugs. Nutrients. 2022 Aug 17;14(16):3367. doi: 10.3390/nu14163367. PMID: 36014874; PMCID: PMC9415189.

[3] Colwell, M.J., Tagomori, H., Chapman, S. et al. Pharmacological targeting of cognitive impairment in depression: recent developments and challenges in human clinical research. Transl Psychiatry 12, 484 (2022). https://doi.org/10.1038/s41398-022-02249-6

[4] Peth-Nui T, Wattanathorn J, Muchimapura S, Tong-Un T, Piyavhatkul N, Rangseekajee P, Ingkaninan K, Vittaya-Areekul S. Effects of 12-Week Bacopa monnieri Consumption on Attention, Cognitive Processing, Working Memory, and Functions of Both Cholinergic and Monoaminergic Systems in Healthy Elderly Volunteers. Evid Based Complement Alternat Med. 2012;2012:606424. doi: 10.1155/2012/606424. Epub 2012 Dec 18. PMID: 23320031; PMCID: PMC3537209.

[5] Trofimiuk E, Walesiuk A, Braszko JJ. St John's wort (Hypericum perforatum) diminishes cognitive impairment caused by the chronic restraint stress in rats. Pharmacol Res. 2005 Mar;51(3):239-46. doi: 10.1016/j.phrs.2004.08.007. PMID: 15661574.

[6] Sun QQ, Xu SS, Pan JL, Guo HM, Cao WQ. Huperzine-A capsules enhance memory and learning performance in 34 pairs of matched adolescent students. Zhongguo Yao Li Xue Bao. 1999 Jul;20(7):601-3. PMID: 10678121.

[7] Blin O, Audebert C, Pitel S, Kaladjian A, Casse-Perrot C, Zaim M, Micallef J, Tisne-Versailles J, Sokoloff P, Chopin P, Marien M. Effects of dimethylaminoethanol pyroglutamate (DMAE p-Glu) against memory deficits induced by scopolamine: evidence from preclinical and clinical studies. Psychopharmacology (Berl). 2009 Dec;207(2):201-12. doi: 10.1007/s00213-009-1648-7. Epub 2009 Sep 16. PMID: 19756528.

[8] Fava A, Pirritano D, Plastino M, Cristiano D, Puccio G, Colica C, Ermio C, De Bartolo M, Mauro G, Bosco D. The Effect of Lipoic Acid Therapy on Cognitive Functioning in Patients with Alzheimer's Disease. J Neurodegener Dis. 2013;2013:454253. doi: 10.1155/2013/454253. Epub 2013 Mar 30. PMID: 26316990; PMCID: PMC4437336.

[9] Noor-E-Tabassum, Das R, Lami MS, Chakraborty AJ, Mitra S, Tallei TE, Idroes R, Mohamed AA, Hossain MJ, Dhama K, Mostafa-Hedeab G, Emran TB. Ginkgo biloba: A Treasure of Functional Phytochemicals with Multimedicinal Applications. Evid Based Complement Alternat Med. 2022 Feb 28;2022:8288818. doi: 10.1155/2022/8288818. PMID: 35265150; PMCID: PMC8901348.

[10] Memory loss: When to seek help https://www.mayoclinic.org/diseases-conditions/alzheimers-disease/in-depth/memory-loss/art-20046326?pg=2

[11] Supplements https://www.aarp.org/health/brain-health/global-council-on-brain-health/supplements/

[12] Regular exercise changes the brain to improve memory, thinking skills https://www.health.harvard.edu/blog/regular-exercise-changes-brain-improve-memory-thinking-skills-201404097110

[13] Cena H, Calder PC. Defining a Healthy Diet: Evidence for The Role of Contemporary Dietary Patterns in Health and Disease. Nutrients. 2020 Jan 27;12(2):334. doi: 10.3390/nu12020334. PMID: 32012681; PMCID: PMC7071223.

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