The 8 Best Anxiety Supplements of 2025, According to Registered Dietitians

Anxiety disorders constitute some of the most common mental health problems in the developed world. Alongside the personal challenges one faces with anxiety, mental health problems are additionally a source of significant economic burden on our society, as they impede our workforce productivity.

There are many treatment options that can help patients suffering from these disorders. Both prescription medications, herbal, anddietary therapies may be employed to treat these disorders. Different patients respond to different treatment strategies. For many patients, prescription medications can successfully treat anxiety, though some may continue to struggle with their symptoms.

The field of complementary and alternative medicine has expanded its scope over the last few years. Studies have shown that up to 43% of patients treated in primary care settings for anxiety disorders have tried complementary and alternative medical techniques to gain relief from their symptoms.^[1]

More than 1 in 2 adults utilize some form of complementary and alternative medical treatments in the United States.(source) These treatments mostly take the form of herbal remedies or dietary supplements.^[2]

We must take into consideration that the Food and Drug Administration (FDA) regulations do not apply to these products. Therefore, these products do not undergo as vigorous scrutiny as FDA-approved medications. Like any other product, they are not without their side effects, thus they are not suitable for everyone.

We bring you current research and guidance from professionals on supplements for anxiety, including who they may help and who should avoid them, as well as some specific supplement options that have shown promise in potentially providing relief for anxiety symptoms.

What is Anxiety?

Anxiety is a normal emotion that causes feelings of tension, worry, and physical symptoms such as increased heart rate, chest pain, nausea, and more. People with anxiety disorders often have recurring unwanted thoughts or fears that will not go away. They may avoid certain situations because of a concerning level of worry. It may be important to note that anxiety is different than fear; Fear is a short-term response to a real threat, while anxiety involves long-term worrying about potential future threats.

Kahlil Gibran, author of The Prophet, states that “We have anxious thoughts because the brain is trying to keep us alive. To the brain, survival is much more important than happiness. Our anxiety does not come from thinking about the future, but from wanting to control it”

Anxiety can be caused by stress, genetics, or life experiences can be very common among mental health problems. Researchers have studied how experiences that can cause anxiety may affect students’ school performance. Their research shows that high anxiety may lead to lower grades. Fortunately anxiety disorders can be treated successfully with therapies. Treatment helps most people live normal, productive lives without anxiety controlling them.

Do Supplements Work For Anxiety?

Supplements are not meant to replace prescription medication without a doctor’s guidance. However, Dr. Schehr notes that some over-the-counter supplements have mechanisms similar to anxiety medications. Dr. Schehr states, “While supplements haven’t undergone the same level of scientific testing as drugs, certain supplements may help manage anxiety symptoms for some.”

Due to less regulation of supplements compared to drugs, it’s difficult to know for sure which product is safest for anxiety relief. That is why Dr. Schehr stresses the importance of discussing supplement options with your healthcare provider before starting anything new. Working with a doctor can help ensure any supplements you take are right for your individual situation and health history.

How We Choose The Best Supplements For Anxiety?

We compiled a list of parameters to examine when selecting a supplement that could help relieve anxiety symptoms. This well-rounded set of guidelines aims to accommodate different people seeking the right option for their individual situations and preferences. Here are the key criteria we considered when selecting the best anxiety supplements:

Price: The cost of a supplement should match its quality and features. We looked at the price range of different brands to get a sense of value.

Testing: We chose supplements that undergo independent lab testing by third parties. This ensures the ingredients and amounts match the label and are free from harmful substances.

Ingredients: High-quality, safe ingredients are important. We assessed each brand’s ingredients to make sure they use science-backed options and strict production standards.

Manufacturing: We evaluated how brands follow manufacturing practices like cGMP certification. We also looked at their commitment to sustainability in their production processes.

Our goal was to have a comprehensive set of guidelines that could help anyone find an anxiety supplement tailored to their individual needs and budget.

Best Anxiety and Stress Relief Supplements On The Market

Here are the supplements that have been carefully chosen based on their effectiveness, safety, and overall quality. Whether you’re looking for potentially quick result or a long-term solution, we’ve got your needs covered. So, with no further delay, let’s jump into our best supplements for anxiety in 2025.

WOWMD Anxiety Shield – Best Supplements for Stress and Anxiety

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*All the prices listed here are as they appear on their websites and are subject to change.

Our Rating

• Comfort 5/5
• Effectiveness 5/5
• Value 4.9/5
• Convenience 4.9/5

WOWMD Anxiety Shield is an herbal supplement designed to reduce stress and promote relaxation. It combines adaptogenic herbs like Ashwagandha and Rhodiola with calming botanicals such as Chamomile and Lemon Balm. This blend helps support mental clarity and emotional well-being by providing a natural way to manage stress and anxiety. It is perfect for those seeking a balanced mood and enhanced vitality.

Key Specs

• Form: Capsules
• Type: Supplement
• Benefit: Reduces stress and anxiety, promotes relaxation, supports mental clarity
• Brand: WOWMD
• Active Ingredients: Ashwagandha, Rhodiola, Chamomile, Lemon Balm, GABA, L-Theanine
• Dosage: 2 veggie capsules daily
• Price: $35.10*

WOWMD Anxiety Shield Pros & Cons

Pros

• Natural and non-habit-forming ingredients
• Supports a calm and balanced mood
• Free from artificial colors and flavors

Cons

• May interact with certain medications
• Some users may experience mild digestive discomfort

Vitapost Stress Support – Best Natural Anxiety Supplement

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*All the prices listed here are as they appear on their websites and are subject to change.

Our Rating

• Comfort 5/5
• Effectiveness 5/5
• Value 5/5
• Convenience 4.9/5

VitaPost Stress Support is a dietary supplement that is designed to help individuals manage stress and improve their overall well-being. It contains a combination of ingredients known for their calming and relaxing properties, such as L-theanine, GABA, and ashwagandha.

By incorporating these ingredients, VitaPost Stress Support aims to support a healthy stress response and promote feelings of calmness and relaxation. It may also help improve sleep quality and support a positive mood.

Key Specs

• Form: Capsules
• Type: Supplement
• Benefit: Supports a Healthy Stress Response, supports relaxation and calmness, and contributes to a positive mood.
• Brand: VitaPost
• Active Ingredients: Chamomile, GABA, L-theanine, Griffonia Seed Ext 5-HTP, Hops, Passionflower, Lemon Balm, Valerian
• Dosage: 1 capsules daily
• Price: $29.95*

VitaPost Stress Support Pros & Cons

Pros

• Helps to reduce stress and anxiety
• promotes relaxation and calmness &improves mood
• supports a strong immune system
• may help to treat insomnia

Cons

• some people may find capsules difficult to swallow
• Result may vary from person to person

NuviaLab Relax – Best Anti-Anxiety Stress Management Supplement

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*All the prices listed here are as they appear on their websites and are subject to change.

Our Rating

• Comfort 4.8/5
• Effectiveness 4.9/5
• Value 4.7/5
• Convenience 4.8/5

NuviaLab Relax is a natural supplement that helps people manage stress and potentially improve their mood by reducing anxiety, depression, mood swings, and irritability. It is available in capsule form and is made with all-natural ingredients.

Key Specs

• Form: Capsules
• Type: Supplement
• Benefit: Reduced stress and anxiety, Improved mood, Better sleep, Enhanced cognitive function
• Brand: NuviaLab
• Active Ingredients: Calmomix, Rhodiolife, Vitamin and mineral complex
• Dosage: 2 capsules
• Price: $49.99*

NuviaLab Relax Pros & Cons

Pros

• NuviaLab Relax helps you relax and de-stress.
• It makes you more productive.
• It improves your emotional well-being.
• It reduces anxiety and depression.
• It fights inflammation.

Cons

• It can only be purchased online

Restilen – Best Supplement For Stress Relief and Relaxation

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*All the prices listed here are as they appear on their websites and are subject to change.

Our Rating

• Comfort 4.7/5
• Effectiveness 4.8/5
• Value 4.7/5
• Convenience 4.8/5

Restilen is a natural stress and anxiety supplement featuring key ingredients like Serenzo from sweet orange peel extract, ashwagandha, and theanine for effective stress relief. while primarily being designed for managing stress, mood and immunity.

Key Specs

• Form: Capsules
• Type: Supplement
• Benefit: Alleviates stress-related symptoms, Reduces fatigue and exhaustion and Promotes a positive mood
• Brand: Restilen
• Active Ingredients: Serenzo™, KSM-66®, Saffr’Activ®, SOD B Extramel® and Green Tea Leaf Extract
• Dosage: 2 capsules per day
• Price: $59.99*

Restilen Pros & Cons

Pros

• All-natural ingredients
• Effective for managing stress and anxiety
• Supports the nervous system
• Sustains energy levels and overall vitality

Cons

• Restilen is only available for purchase online
• Slightly expensive compared to other

Goli Ashwagandha Gummies – Best Gummies For Anxiety

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*All the prices listed here are as they appear on their websites and are subject to change.

Our Rating

• Comfort 4.7/5
• Effectiveness 4.8/5
• Value 4.8/5
• Convenience 4.7/5

Goli Ashwagandha is a natural gummy product in mixed berry flavor that focuses on one main ingredient: the herb ashwagandha. This plant suggests to offer a number of benefits including reducing feelings of stress and anxiety, improving sleep, and enhancing memory and cognitive performance. In addition, it elevates general health and strengthens immune functioning.

Key Specs

• Form: Gummies
• Type: Supplement
• Benefit: Helps reduce stress and tension, promotes memory and concentration, reduces and maintains healthy body weight
• Brand: Goli
• Active Ingredients: KSM-66® Ashwagandha, Vitamin D and Pectin
• Dosage: 1-2 gummies, 3 times daily
• Price: $17.50*

Goli Ashwagandha Gummies Pros & Cons

Pros

• Goli Ashwagandha Gummies can improve sleep quality
• This product reduces stress and anxiety
• It can improve memory and mental functioning
• Goli Ashwagandha is gluten free and suitable for vegans
• The product is chewable and tasty

Cons

• It contains some sugar and carbs, and 25 calories per serving
• More flavor options would be preferable
• The focus is on one primary active ingredient

Pure Encapsulations Magnesium Glycinate – Best Magnesium Supplements For Anxiety

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*All the prices listed here are as they appear on their websites and are subject to change.

Our Rating

• Comfort 3.9/5
• Effectiveness 4/5
• Value 3.8/5
• Convenience 3.9/5

Pure Encapsulations’ Magnesium Glycinate is a dietary supplement containing a highly absorbable form of magnesium that supports various bodily functions, including bone health, heart and nervous system function, and muscle performance.

This form of magnesium is bonded to glycine, an amino acid, making it easier for the body to absorb and utilize. our review of WOWMD Magnesium Glycinate, indicate that magnesium glycinate has the potential to promote relaxation in both the mind and body, potentially alleviating stress and anxiety that may disrupt sleep.

Key Specs

• Form: Capsules
• Type: Supplement
• Benefit: Support cognitive and neuromuscular function, Promotes healthy cardiovascular function
• Brand: Pure Encapsulations
• Active Ingredients: Magnesium
• Dosage: 1-4 capsules daily
• Price: $26.00*

Pure Encapsulations Magnesium Glycinate Pros & Cons

Pros

• Made with high-quality vegan ingredients
• It is non-GMO, gluten-free, vegan

Cons

• Some users have reported side effects
• May not be suitable for people with certain medical conditions

Nordic Naturals ProOmega 2000 – Best Omega-3 Supplements for Anxiety

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*All the prices listed here are as they appear on their websites and are subject to change.

Our Rating

• Comfort 3.8/5
• Effectiveness 3.9/5
• Value 3.7/5
• Convenience 3.8/5

Nordic Naturals ProOmega 2000 is a powerful dietary supplement that packs an impressive 2000 mg of EPA and DHA, essential omega-3 fatty acids, into just two easily digestible soft gels. What sets this product apart is its highly absorbable 90+% triglyceride molecular form, ensuring efficient delivery of these vital nutrients to the body.

The potential alleviation of anxiety symptoms has been associated with the consumption of omega-3 fatty acids, highlighting their role in modulating neurobiological processes that contribute to emotional well-being.

Key Specs

• Form: Soft gels
• Type: Supplement
• Benefit: Supports brain, eye and heart health
• Brand: Nordic Naturals
• Active Ingredients: EPA (Eicosapentaenoic Acid), DHA (Docosahexaenoic Acid),
  Other Omega-3s
• Dosage: 2 soft gels daily
• Price: $49.95*

ProOmega 2000 Pros & Cons

Pros

• Supports eye, joint, and immune health
• Supports cardiovascular function by maintaining healthy triglyceride

Cons

• It has a very strong fish odor and taste
• Expensive compared to other

Natural Vitality CALM Magnesium – Best Magnesium Citrate Supplement for Anxiety

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*All the prices listed here are as they appear on their websites and are subject to change.

Our Rating

• Comfort 3.7/5
• Effectiveness 3.8/5
• Value 3.8/5
• Convenience 3.7/5

Natural Vitality CALM Magnesium is a powdered supplement designed to combat stress. It is enriched with magnesium, an essential element that plays a crucial role in more than 300 bodily processes. This magnesium supplement aids in maintaining healthy muscle and nerve function, potentially fostering emotional balance, alleviating tension, and promoting relaxation.

Key Specs

• Form: Powdere
• Type: Supplement
• Benefit: Helps to relieve stress, Tension and Relax your mind
• Active Ingredients: Magnesium carbonate, citric acid, organic orange flavor, organic stevia (leaf) extract
• Dosage: Once Daily
• Price: $21.99*

Natural Vitality CALM Magnesium Pros & Cons

Pros

• It is gluten-free, non-GMO, and vegan.
• Supports overall nerve and brain function
• Maintain healthy blood pressure levels

Cons

• Some users do not like the taste
• It may cause a mild side effect

Now True Calm – Best Vegan Anxiety Supplement

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*All the prices listed here are as they appear on their websites and are subject to change.

Our Rating

• Comfort 3.6/5
• Effectiveness 3.7/5
• Value 3.7/5
• Convenience 3.8/5

True Calm is a specially crafted blend of amino acids and essential cofactor nutrients designed to enhance the regular production and functioning of calming neurotransmitters within the brain. It features GABA and glycine, two amino acids that encourage a tranquil state of mind, as well as taurine, another amino acid recognized for its calming effects.

Key Specs

• Form: Capsules
• Type: Supplement
• Benefit: Promote relaxed state of mind & Calming properties
• Active Ingredients: Niacin, Vitamin B6, Magnesium, GABA , Glycine, Taurine, nositol and Valerian
• Dosage: 1 capsule 1 to 3 times daily
• Price: $19.99*

Now True Calm Pros & Cons

Pros

• This product is free from dairy, nuts, soy, eggs, and suitable for vegans.
• It aids in the regulation of neurotransmitters in the brain.

Cons

• It may cause side effects in some individuals

What to Look for When Shopping for a Supplement for Anxiety?

Given that there is no single vitamin or mineral that has definitively been identified as the most effective remedy for anxiety, it’s essential to engage in a conversation with your healthcare professional to determine the supplement that may be most suitable for your needs.

Your healthcare provider can review your medical history and conduct tests to assess if any nutrient deficiencies might be contributing to your anxiety. They will take your unique circumstances into account before suggesting a supplement.

Additionally, it’s beneficial to consider a few other factors when in search of an anxiety supplement that aligns with your requirements.

Form: Supplements come in different forms like capsules, chewables, gummies, and lozenges. Many options on this list are capsules or softgels, but some brands offer gummies too which may be easier to take for some individuals.

Serving size: Check the recommended daily amount and number of pills/gummies. Consider what dosage form you prefer – one pill a day or divide it into multiple servings. Your doctor can help determine the right amount with you.

Cost: Prices vary between brands. More expensive doesn’t always mean better. We included the cost per daily serving to make comparisons easier. Larger formulas with multiple ingredients tend to cost more than single-ingredient supplements.

Be sure to talk to your healthcare provider about any medications you take. You want to avoid unwanted interactions between supplements and prescription drugs.

Can Supplements Help Anxiety?

The foods we eat can impact how well we handle stress. Different components of a diet like trans fats, added sugars, and ultra-processed carbohydrates are considered “inflammatory” foods and may cause issues with mood if heavily consumed. On the other hand, omega-3 fatty acids from oily fish and certain nuts and seeds are thought to reduce inflammation and support mental wellness.

Taking anxiety supplements may help balance a person’s nutritional intake and fill in possible nutritional gaps. This prepares the body to better deal with stressful times. However, supplements alone will not treat anxiety disorders nor make symptoms go away.

If anxiety is affecting your life, talking to a healthcare professional is important. They can help determine if supplements are suitable for your needs or if another treatment, such astherapy, is also needed. The goal is to find the best-individualized approach.

Natural Anxiety Supplements: Do These At-Home Relief Products Work?

Several herbal remedies have been studied as a treatment for anxiety, but more research is needed to understand the risks and benefits. This article will go over some of the alternative remedies for the treatment of anxiety. The provided information is intended solely for informational purposes and is not meant to be construed as prescriptive or suggesting specific actions.

If you are thinking of using these products to treat your anxiety disorder, you should have an open discussion with your doctor. You need to ensure that there are no drug-drug interactions with your other medications, and that there are no significant side effects that may preclude your use of these products.

Let us dive in and look at some of these best anxiety supplements that may have beneficial effects for anxiety patients struggling with anxiety. We can divide them into two broad categories.

#1 Herbal Therapies

Several herbal therapies have successfully relieved anxiety symptoms. Manipulation of the neurotransmitter pathway involving gamma-aminobutyric acid is the one critical link behind the success of most of these therapies Let us look at some of them:

Saffron

Saffron is derived from the plant Crocus sativus. This plant is heavily cultivated in countries like Iran, India, and Greece. In one clinical trial, saffron was compared to placebo, and the patients in the saffron group had better improvements in their anxiety symptoms.^[3]

In a different trial, patients who were already on medical treatment were given additional saffron versus placebo, and the former group did better.^[4]

It is available as an 88.5 mg capsule, which you can take once daily if appropriate with medical guidance.

St. John’s Wort

St John’s Wort is derived from the plant Hypericum perforatum. It is mostly used for the treatment of major depression. There are no trials that show that St. John’s Wort is useful for the treatment of anxiety without depression.

However, study showed that the use of St John’s Wort in patients with significant depression yielded beneficial secondary effects with a reduction in anxiety as well.^[5]

The usual dose is 300 mg, which you can take once daily if appropriate. CAUTION: However, there is a significant and serious drug interaction with St. John’s Wort and medications that are known as selective serotonin reuptake inhibitors (SSRI), which can cause serotonergic syndrome. The supplement interacts with many medications and can cause serious side effects. Consult with your doctor before taking St. John’s wort if you take any other medications

Passion flower

Passion flower is derived from the plant Passiflora incarnata. Its effects are generally very mild, and therefore, it is not used in isolation but rather in combination with other herbs.

It was used in a trial to see if the patients who experienced anxiety before a surgical procedure would have a reduction in their symptoms, and a benefit was seen with its use.^[6] The usual dose is 500 mg daily.

Valerian

Valerian has been derived from the plant Valeriana officinalis. Trial data for its efficacy as an anxiolytic has been lacking. However, it has been proposed that since it has sedating properties, it may help with anxiety as well. The recommended dosage is one capsule of 500 mg daily if appropriate.

Chamomile

Chamomile is obtained from the plant Matricaria recutita. It is one of the oldest herbs and in use for thousands of years. A clinical trial compared chamomile extract with placebo in patients with a generalized anxiety disorder, and a benefit was shown.8 You can consume this supplement through chamomile tea or capsules.^[7]

Keenmind

Keenmind is yielded from the plant Bacopa monniera. There is a clinical study that showed it had clinically significant anxiety-reducing properties in a subset of patients. Besides, it also enhanced the speed of new information processing, verbal learning rate, and memory consolidation. The recommended dosage is one capsule of 320 mg daily if appropriate.^[8]

Rhodiola

Rhodiola is derived from the plant Rhodiola Rosea. In a clinical trial that enrolled patients between the ages of 34 and 55, significant improvement in anxiety symptoms occurred with the use of this herb. Some adverse effects noted were dizziness and dry mouth. The recommended dosage is one 500 mg capsule daily if appropriate.^[9]

Scullcup

This herb is derived from Scutellaria lateriflora. It has shown anxiety-reducing benefits in a clinical trial as well.^[10] The recommended dosage is 850 mg daily if appropriate.

Silexan

Silexan is a new oral lavender oil capsule preparation. It was studied in a study in which the participants took six weeks of silexan compared to a common anxiety medication lorazepam.^[11]

After six weeks, silexan effectively reduced generalized anxiety as compared to lorazepam. These similar and effective results are crucial due to lorazepam having a high incidence of causing sedation and a high potential for drug abuse; Lorazepam is not advised to take for a prolonged period.

Lemon Balm

Lemon balm is derived from Melissa officinalis leaf extract. A clinical trial using lemon balm looked at a primary outcome measure of the reduction in heart palpitations, and a secondary outcome measure of the decrease in anxiety showed a promising effect of reducing the anxiety score.^[12] The recommended dosage is 500 mg once daily if desired.

*Note – It is not intended to treat clinical depression or anxiety disorders. Keep in mind that herbal supplements can have varying effects on individuals, and it’s essential to approach them with caution and under professional guidance.

#2 Natural Vitamins and Dietary Supplements for Anxiety

Some of the most common natural vitamins for anxiety include:

Omega-3 fatty acids

Omega-3s are found in fish oil. There have been several clinical trials that have established the anxiety-reducing effects of these supplements. The mostavailable formulations contain two different fatty acids, EPA and DHA packaged together. You can take one capsule daily if desired.

Vitamins A, C, and E

All of these vitamins share the characteristic that they all have antioxidant properties. A clinical trial enrolled patients with stress-induced psychiatric disorders, mainly anxiety and depression. All of the patients had reduced blood levels of vitamins A, C, and E. They were all given vitamin supplementation to bring their blood levels up, which also improved anxiety symptoms.^[13]

Multivitamin tablets usually contain all these vitamins. You can take one daily if desired.

L-lysine and L-arginine

These essential amino acids have been shown to improve anxiety symptoms. In clinical trials, treatment with these amino acids decreased the symptoms of anxiety in patients who had high levels of baseline anxiety.^[14]

Both of these are present together in amino acid supplement pills. Take once daily if desired.

Vitamin B6 and Folate

Vitamin B levels are essential for the creation of serotonin neurotransmitters, which play a crucial role in signal transmission in the central nervous system. In a clinical study, decreased levels of vitamin B6 and folate caused increased symptoms of depression and anxiety. Therefore, increasing their blood levels with supplementation can have beneficial effects.^[15]

Multivitamin tablets usually contain all these vitamins. You can take one daily if desired.

When To See a Mental Health Professional For Anxiety?

It isn’t always easy to know if you’re just feeling stressed from life or dealing with a real mental health problem. Only certain trained professionals like psychologists, psychiatrists, or licensed counselors have the skills to properly assess your emotional well-being.

They can determine if you’re experiencing a normal reaction to stress or something more serious. They will also be able to recommend the best treatment approach if needed. When it comes to your mental health, it’s important to get an evaluation from a medical provider who is qualified to diagnose and help with any issues.

However, there are some things to watch out for that could indicate it’s time to see a mental health professional:

• Feeling depressive symptoms for more than two weeks
• Losing interest in hobbies and spending time with others
• Major changes in sleep and appetite
• Using more drugs or alcohol than before
• Hearing or seeing things that are not really there

If any of those signs lasts for more than a couple of weeks, it’s a good idea to talk to a doctor, therapist, or counselor. They can properly evaluate your symptoms and determine the best treatment if needed.

Final Verdict

Anxiety is a common concern that can impact our lives. While there are many treatments available, such as prescription medications and dietary supplements, it’s important to remember that not all solutions work the same for everyone.

Supplements, which come in various forms and may help with anxiety symptoms, should be discussed with your healthcare provider. They can recommend the right approach based on your unique needs and medical history. Remember that anxiety can be influenced by various factors, including diet and nutrition, and supplements can be part of a holistic approach to managing it.

However, if anxiety significantly affects your daily life, it’s essential to consult a mental health professional for a proper evaluation and personalized guidance. Your well-being is important, and there are experts who can help you find the best way to address your concerns.

ALSO READ – The Best Ashwagandha Gummies for a Stress-Free 2025

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