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Overview
Young individuals enjoy great joint flexibility. Their joints are much more resilient to damage and if injured, typically recover more quickly as compared to joints in older adults. As we age, muscle tone declines, joints lose lubrication, arthritis may develop, and pain, stiffness, and inflammation become daily issues and are all reasons for the loss in mobility.
Arthritis affects more than one-third of the U.S. population and is a primary cause of disability for adults. There are various types of arthritis, but osteoarthritis is the most common and there is no cure.[1] “Chronic pain caused by arthritis affects millions of people in the United States every year. About one in four adults with arthritis—15 million people—report experiencing severe joint pain related to arthritis”, reports by CDC.
Joint pain supplements are meant to not only ease aches and pains associated with aging but potentially slow down the progression of joint degeneration. “Severe joint pain is more common among adults with arthritis who also have other chronic conditions including diabetes (40.9%), heart disease (34.1%), and obesity (31.7%), and among adults with a disability (45.6%)”, studies done by CDC.
Modern joint support supplements include active ingredients such as glucosamine, chondroitin, or Methylsulfonylmethane (MSM) that are meant to relieve pain and inflammation, enhance joint mobility, and potentially preserve joint cartilage.
Some supplement for joints and bones will additionally contain ingredients like collagen peptides, hyaluronic acid, or natural extracts to further support joint health and function. Here’s a look at ingredients and what the existing research says about them.
Our Top Picks of 2025
Best Joint Support Supplements: Super Derm Complex
Read The ReviewsBest Joint Support Supplements: JointXL Plus
Overall Best: VitaPost ProJoint Plus
Docter Formulated Joint Health Supplement: Bio Dynamix Joint Genesis
Best Gummies For Joint Health: Joint Restore Gummies
Best Supplements For Pain and Inflammation: Relief Factor
Best Proteolytic Enzymes For Arthritis: Heal N Soothe
Best Turmeric Supplement For Joint Pain: Turmeric Curcumin Plus
Best Glucosamine Chondroitin Supplements For Joint Pain: Super Joint Support
Best For Knees: Joint N-11
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*All individuals are unique. Your results can and will vary.
Best Joint Health Supplement: 1MD MoveMD
Best Algae Supplement For Joint: Red Algae Calcium
Best Krill Oil Supplement For Joint: 1MD KrillMD
Best Turmeric Curcumin Supplement: CurcuminMD
Best For Athletes: Physio Flex Pro
Best Vitamins For Joint Health: Primal Harvest Primal Flex
Best Supplement For Joint Pain Relief: Performance Lab Flex
Best Joint Support Supplement: Instaflex Advanced
Best Supplement For Joint Mobility:Jocko Joint Warfare
Best Fish Oil Supplement For Joint Pain:Omega XL
Best Supplement For Osteoarthritis: Osteo Bi-Flex
Best Supplements For Arthritis Pain: Aleve
How We Researched & Picked?
In deciding on the best joint pain supplements on the market, we analyzed the formula of each supplement, specifically the active ingredients and doses, as well as verifying whether each supplement is supported by clinical studies or not. We want to ensure the ingredients are helpful in promoting joint health and relieving arthritis-related symptoms.
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*All individuals are unique. Your results can and will vary.
We have eliminated any joint pain supplements that contain potentially harmful ingredients such as preservatives, artificial colors, fillers, binders, or additives. Such ingredients pose questions about safety and purity and can lead to discomforting side effects or adverse reactions.
Our selection of supplements for knee pain is sound, as we have looked at quality first and foremost and it is essential to us that each supplement below has the potential to truly support joint health.
The Best Joint Pain Supplements of 2025
In this comprehensive review of Glucosamine, Chondroitin, MSM, and Boswellia supplements to help joint pain, you’ll learn the pros and cons for the best joint supplements mentioned below:
JointXL Plus – Best Joint Support Supplements
*All the prices listed here are as they appear on their websites and are subject to change.
Our Rating
JointXL Plus is an all-natural maximum strength joint health formula. Its proprietary blend is specifically designed to tackle the root causes of joint discomfort and stiffness naturally.
Developed by healthcare professionals, this powerful joint supplement is formulated to rebuild damaged cartilage, lubricate stiff joints, enhance range of motion, boost mobility and flexibility, soothe inflamed joints, and reduce pain linked to arthritis. Each bottle of JointXL Plus is packed with all-natural ingredients, perfectly balanced in their optimal quantities to work together and provide unmatched results
Key Specs
- Form: Capsules
- Type: Supplement
- Benefits: Support Immune System, Reduce Inflammation, Enhance Joint Strength and Relieve Discomfort
- Brand: JointXL Plus
- Active Ingredients: Glucosamine Sulfate Indian Frankincense Chondroitin Sulfate, Turmeric, Quercetin, Methionine, Methylsulfonylmetha and Bromelain
- Dosage: 3 capsules daily before a meal
- Price: $54.00
Pros & Cons of JointXL Plus
Pros
- Laboratory tested Ingredients
- Natural, Safe, effective & Drug-Free Formula
- Improves Joint health and mobility
- Eliminates Joint Pain
- 100% Money-Back Guarantee
- Manufactured Inan Fda-Compliant Facility
Cons
- Results may vary among individuals
- limiting purchasing options
Super Derm Complex
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*All individuals are unique. Your results can and will vary.
*All the prices listed here are as they appear on their websites and are subject to change.
Our Rating
Super Derm Complex is a powerful collagen supplement designed to improve the health and appearance of skin, hair, nails, and joints. It features five types of collagen, each chosen for its specific benefits, from reducing wrinkles and promoting skin hydration to supporting joint flexibility and reducing inflammation. This formula is ideal for those looking to enhance their overall wellness, as it also aids in muscle development and metabolism.
Key Specs
- Form: Capsules
- Type: Dietary Supplement
- Benefit: Enhance skin hydration, improve nail and hair health, support healthy joints
- Brand: Super Derm Complex
- Active Ingredients: Type I collagen peptide, Type II collagen peptide, Type III collagen peptide, Type IV collagen peptide, and Type V collagen peptide
- Price: $54.00*
Super Derm Complex Pros & Cons
Pros
- Reduces visible signs of aging like fine lines and wrinkles.
- Enhances joint flexibility and mobility.
- Boosts overall skin health and radiance.
- Helps strengthen nails and improve hair shine.
Cons
- Results may take several weeks to become noticeable
- Not suitable for individuals with allergies to animal-based products
VitaPost ProJoint Plus – Overall Best Joint Supplement
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*All the prices listed here are as they appear on their websites and are subject to change.
Our Rating
VitaPost ProJoint Plus is one of the best joint supplement that improves the health of joints. It supports the health of the cartilage and promises to increase overall mobility, thanks to a natural blend of herbal extracts.
Key Specs
- Form: Capsules
- Type: Supplement
- Benefit: Supports cartilage health, joint health and healthy joint mobility
- Brand: VitaPost
- Active Ingredients: Glucosamine Sulfate, Quercetin, Methylsulfonylmethane, Boswellia Extract, Turmeric, Bromelain, Methionine, Chondroitin Sulfate
- Dosage: Take 3 capsules per day
- Price: $29.95*
VitaPost ProJoint Plus Pros & Cons
Pros
- Science-backed formula – increased mobility and flexibility in major and minor joints
- Contains key ingredients such as glucosamine and MSM, but also natural herbal extracts: Boswellia, turmeric, bromelain, quercetin
- All ingredients are supported by clinical studies
- GMP quality assured
Cons
- Must be taken on a daily basis for the full effect
- Only available online & no trial period offered
BioDynamix Joint Genesis – Docter Formulated Joint Health Supplement
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*All the prices listed here are as they appear on their websites and are subject to change.
Our Rating
Joint Genesis is a revolutionary solution addressing age-related joint degeneration by targeting the root cause – the loss of hyaluronan. Its unique formula sets Joint Genesis apart, featuring four scientifically-backed joint nutrients and Mobilee, a patented substance that enhances hyaluronan molecules in synovial fluid tenfold.
Key Specs
- Form: Capsules
- Type: Supplement
- Benefit: Supports joint health and healthy joint mobility
- Brand: Bio Dynamix
- Active Ingredients: Ginger Powder, Boswellia Extract, Hyaluronic Acid Matrix, Pine Bark Extract, Black Pepper
- Dosage: One capsule per day
- Price: $59.00*
Bio Dynamix Joint Genesis Prop & Cons
Pros
- Ingredients are secure and supported by research
- It helps joints move freely without rubbing against each other
- It contains nutrients that support optimal joint health by nourishing the cartilage tissue
- It is vegan-friendly without soy, nuts, dairy, eggs, crustaceans, gluten, or GMOs
Cons
- The results vary by person
- No free samples
Joint Restore Gummies – Best Gummies For Joint Health
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*All the prices listed here are as they appear on their websites and are subject to change.
Our Rating
Joint Restore Gummies offer a breakthrough solution for knee discomfort and overall joint health. These gummies feature a special mix of natural ingredients with anti-inflammatory properties, aiming to improve joint function.
The gummy format makes it a convenient and enjoyable way to tackle joint concerns, offering a tasty and effective solution for joint support.
Key Specs
- Form: Capsules
- Type: Supplement
- Benefit: Support joint health and mobility
- Brand: Prosper Wellness
- Active Ingredients: Boswellia Serrata Extract, Boswellia Serrata Extract
- Dosage: One capsule per day
- Price: $79.97*
Joint Restore Gummies Pros & Cons
Pros
- Support joint health and mobility
- Better joint health
- Easy to take
- Suitable for most people
Cons
- Gummies can be more expensive than other joint support supplements
- The appealing taste of gummies may lead to accidental overconsumption, affecting the recommended dosage
Relief Factor – Best Supplements For Pain and Inflammation
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*All the prices listed here are as they appear on their websites and are subject to change.
Our Rating
Relief Factor is a powerful drug-free botanical research-based formula designed to help relief body’s inflammatory response, common pain and discomfort, such as joint and muscular pain, as well as the restoration of flexibility and mobility.
Key Specs
- Form: Capsules
- Type: Vitamin & Supplement
- Benefit: Alleviates joint discomfort, reduces body pain, relieves the body’s inflammatory response
- Brand: Relief Factor
- Active Ingredients: Icariin, Resveratrol, Omega-3, Turmeric
- Dosage: Take 2 capsules and 2 softgels three times a day
- Price: $79.95*
Relief Factor Pros & Cons
Pros
- Reduces inflammation in the muscles and joints
- Enhances healthy muscles and joints
- It contains all natural ingredients
- Organic product based on fish oil
Cons
- Requires taking a minimum of 2 capsules and 2 soft gels every day
- Individual results can and will vary
Heal N Soothe – Best Proteolytic Enzymes For Arthritis
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*All the prices listed here are as they appear on their websites and are subject to change.
Our Rating
Heal-n-Soothe is an organic supplement by Living Well, designed to alleviate pain and inflammation associated with arthritis. Combining systemic enzymes and 12 healing plant extracts, it promotes healthy circulation and accelerates wound healing. This easy-to-use capsule formula aids in relieving various pains, from exercise soreness to chronic joint issues.
Key Specs
- Form: Capsules
- Type: Supplement
- Benefit: Maximizes natural joint support, supports joint health, comfort and flexibility and healthy immunity system
- Brand: Living Well Nutraceuticals
- Active Ingredients: Bromelain, Turmeric, Boswellia Extract, Mojave Yucca Root
- Dosage: 3 capsules per day on an empty stomach
- Price: $49*
Heal N Soothe Pros & Cons
Pros
- It soothes the swelling and inflammation allied with arthritis
- The results are backed by clinical research and studies
- It reduces free radicals in the body
- It may ease tender joints
Cons
- There are no notable side effects with this product, according to the customer reviews
- It contains rice concentrate, which may be an allergen for some users
Turmeric Curcumin Plus – Best Turmeric Supplement For Joint Pain
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*All the prices listed here are as they appear on their websites and are subject to change.
Our Rating
Turmeric Curcumin Plus is a healthy turneric supplement which supports joint and muscle wellness, brain and cardiovascular health, and it can help you lose weight. In addition, it strengthens the immune system.
Key Specs
- Form: Capsules
- Type: Supplement
- Benefit: Helps support a healthy immune system, enhances muscle and joint health, promotes healthy cognitive functioning
- Brand: Vita Balance
- Active Ingredients: Turmeric, Curcumin, BioPerine
- Dosage: Take 2 capsules once daily
- Price: $23.95*
Turmeric Curcumin Plus Pros & Cons
Pros
- Turmeric Curcumin Plus supports joint and muscle health.
- This supplement strengthens the immune system.
- The product helps to improve brain health.
- Turmeric Curcumin Plus is reasonably priced.
Cons
- High demand leads to low stock at times
Super Joint Support – Best Glucosamine Chondroitin Supplements
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*All the prices listed here are as they appear on their websites and are subject to change.
Our Rating
Super Joint Support is an advanced formula that has been designed using natural ingredients to maintain joint flexibility and mobility, and reduce pain.
Key Specs
- Form: Capsules
- Type: Supplement
- Benefit: Joint Health
- Brand: Living Well Nutraceuticals
- Uses: Reduce Joint Swelling and Discomfort, Improve Flexibility and Mobility, and Enhance Muscle Recovery.
- Active Ingredients: Ascorbic Acid, White Willow Bark Extract, DL-Phenylalanine, (MSM), roitin Sulfate Sodium, Glucosamine Sulfate Potassium, Ancient Ionic Sea Minerals, Vitamin B12, Vitamin K2
- Dosage: Take 6 capsules daily
- Price: $49.95*
Super Joint Support Pros & Cons
Pros
- It reduces joint pain, inflammation, and stiffness
- It may help improve joint flexibility
- It boosts a person’s immune systems
- It enhances stamina and provides more energy to go through the day
- It helps in the production of lubrication within the joints to reduce friction thus preventing further damage
- It replenishes the lost micronutrients within the bones, joints, and cartilage so that they can heal and further damage is avoided
- It improves life quality because it enables you to do activities that you have avoided before due to joint pain
Cons
- It is not clinically proven and there are not backed by any scientific studies and evidence making it arguable
- Do not exceed the recommended dosage of this product
- It is relatively expensive
Joint N-11 – Best Joint Supplements For Knees
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*All the prices listed here are as they appear on their websites and are subject to change.
Our Rating
Joint N-11 is a natural joint pain relief supplement which improves joint and bone health and decreases pain and inflammation in the joints. It restores flexibility and mobility in the knees, back, and hips and supports the hands and wrists.
Key Specs
- Form: Capsules
- Type: Supplement
- Benefit: Protects the joint cartilage for easy movement, supports against nagging joint pain, provides maximum flexibility and mobility
- Brand: Zenith Labs
- Active Ingredients: Ginger Root Powder, Boswellia Serrata, Turmeric
- Dosage: Take 2 capsules a day with breakfast
- Price: $49*
Joint N-11 Plus Pros & Cons
Pros
- Joint N-11 reduces joint pain and inflammation.
- The product improves flexibility and mobility.
- Joint N-11 supports bone health.
- It protects the joint cartilage.
- The product helps to repair damage to the joints and cartilage.
Cons
- It may interact with some common medications.
- It includes soy and rice flour, which are common allergens.
1MD MoveMD – Best Joint Health Supplement
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*All the prices listed here are as they appear on their websites and are subject to change.
Our Rating
Move MD is an organic joint supplement which can ease joint pain, inflammation, and stiffness and make movement easier and less painful. It’s high in antioxidants which repair joint damage and protect them from future harm.
Key Specs
- Form: Capsules
- Type: Supplement
- Benefit: Reduces Joint Discomfort, helps maintain connective tissue, increases the mobility and flexibility of the joints
- Brand: 1MD Nutrition
- Active Ingredients: Boswellia Serrata, Chicken Collagen, Hyaluronic Acid, Astaxanthin, Eggshell Membrane Collagen
- Dosage: 1 capsule per day
- Price: $40.99*
Move MD Pros & Cons
Pros
- Move MD can decrease joint pain and swelling.
- It can increase lubrication and ease stiffness.
- This supplement improves flexibility and mobility.
- It supports a strong immune system.
Cons
- The product is not suitable for vegetarians.
- Results vary from individual to individual.
Icelandic Red Algae Calcium – Best Algae Supplements For Joint
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*All the prices listed here are as they appear on their websites and are subject to change.
Our Rating
Icelandic Red Algae Calcium is a supplement with the primary ingredient of red algae calcium that is designed to decrease pain and swelling in the joints, improve flexibility and mobility, promote stronger bones and teeth, strengthen immunity, and improve cartilage health.
Key Specs
- Form: Capsules
- Type: Supplement
- Benefit: Supports flexible and resilient ligaments, tendons and connective tissues
- Brand: Icelandic
- Active Ingredients: Red Algae Calcium, Vitamin K2, Citrus, Magnesium, Vitamin D3, Organic Kale
- Dosage: 3 capsules with a meal, everyday.
- Price: $59.95*
Icelandic Red Algae Calcium Pros & Cons
Pros
- The product is formulated with 100% organically-sourced ingredients
- It can decrease joint pain
- The supplement can improve flexibility and mobility
- It may promote the strength of the bones
Cons
- You can only buy this supplement online
- This is a very popular supplement which may sometimes go low stock
1MD KrillMD – Best Krill Oil Supplement For Joint
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*All the prices listed here are as they appear on their websites and are subject to change.
Our Rating
1MD KrillMD is a dietary supplement formulated with highly potent Antarctic Krill oil, rich in omega-3 fatty acids EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid). Additionally, it features antioxidant astaxanthin and krill phospholipids, enhancing ingredient absorption into the body. This supplement effectively combats stress in the body, promoting enduring joint, heart, and brain health. Elevate your well-being with 1MD KrillMD.
Key Specs
- Form:Capsules
- Type:Supplement
- Benefit:Support cognitive, heart, and joint health
- Brand:1MD Nutrition
- Active Ingredients:Krill Oil, EPA, DHA, Phospholipids, Astaxanthin
- Dosage:2 soft gel capsules with plenty of water every day
- Price:$40.99*
1MD KrillMD Pros & Cons
Pros
- It supports cognitive, heart, and joint health
- Claims to be formulated with clinically proven pure krill oil
- It may reduce oxidative damage caused by free radicals
- The product is free from gluten, dairy, non-GMO, soy, and preservatives
Cons
- It may not be suitable for users with fish allergy
- The product should be take up to 3 months for the full effects
CurcuminMD – Best Turmeric Curcumin Supplement For Joint
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*All the prices listed here are as they appear on their websites and are subject to change.
Our Rating
CurcuminMD is a potent formula with anti-inflammatory properties that can reduce swelling and pain in the joints. This is a healthy supplement full of antioxidants which can raise immunity and support heart and brain wellness.
Key Specs
- Form:Capsules
- Type:Supplement
- Benefit:Improves cognitive health, relieves joint stiffness, protects joints and tissues
- Brand:1MD Nutrition
- Active Ingredients:Curcumin, Boswellia Serrata
- Dosage:Take 1 capsule twice a day
- Price:$36.99*
CurcuminMD Pros & Cons
Pros
- It can reduce joint pain and swelling.
- CurcuminMD improves brain health.
- It supports a healthy heart.
- CurcuminMD is suitable for vegans.
Cons
- You may have mild side effects like headaches or nausea.
Physio Flex Pro – Best Joint Supplement For Athletes
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*All the prices listed here are as they appear on their websites and are subject to change.
Our Rating
Physio Flex Pro is a research-backed joint support complex featuring natural ingredients to nourish and lubricate joints, relieve pain, and protect cartilage. Composed of eight organically-sourced components, this premium supplement reduces joint pain and inflammation, eases stiffness, and promotes the repair and regeneration of joint and cartilage tissue
Key Specs
- Form: Capsules
- Type: Supplement
- Benefit: Decreases stiffness, reduces joint pain and inflammation, enhances flexibility and mobility
- Brand: Physio Flex Pro
- Active Ingredients: Glucosamine HCI, Chondroitin Sulfate, Bromelain, Ginger Extract, Turmeric Extract, MSM, Bioperine, Selenium
- Dosage: 2 capsules everyday at any hour.
- Price: $58*
Physio Flex Pro Pros & Cons
Pros
- 100% organic ingredients backed by scientific research
- Enhances healthy muscles and joints
- It may strengthen immune functioning
- The product improves flexibility and mobility
Cons
- The supplement will work differently for different users
- You can only purchase the product on the official website.
Primal Harvest Primal Flex – Best Vitamins For Joint Health
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*All the prices listed here are as they appear on their websites and are subject to change.
Our Rating
Primal Harvest Primal Flex is a premium holistic formula designed for healthier joints, enhanced mobility, and overall wellness. This potent blend features BioCell Collagen®, vitamin C, and magnesium to support joint health. It also includes Boswellia serrata, turmeric, ashwagandha, and astaxanthin for additional benefits. The product promises to improve your flexibility, mobility, and allow you to be more active.
Key Specs
- Form: Capsules
- Type: Supplement
- Benefit: Decreases discomfort naturally and maintains optimal inflammatory responses, fights pain naturally
- Brand: Primal Harvest
- Active Ingredients: Vitamin C, Magnesium, Turmeric, Ashwagandha, Collagen Type II
- Dosage: 2 capsules per day
- Price: $49.95*
Primal Flex Pros & Cons
Pros
- The product supports overall joint health
- The supplement is high in anti-inflammatory agents
- It could improve your activity levels
- It might strengthen the immune system
Cons
- It may not be suitable for vegetarians or vegans
- Boswellia serrata may cause some mild side effects
Performance Lab Flex – Best Supplement For Joint Pain Relief
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*All the prices listed here are as they appear on their websites and are subject to change.
Our Rating
Performance Lab Flex is a joint health supplement formulated with all-natural ingredients that support ligaments, tendons, and cartilage, improve joint lubrication, and is known for herbal relief for stiff, achy joints.
Key Specs
- Form: Capsules
- Type: Supplement
- Benefit: Supports flexible and resilient ligaments, tendons and connective tissues
- Brand: Performance Lab
- Active Ingredients: CurcuWIN Turmeric, AprèsFlex Boswellia serrata, Glucosamine, Phytodroitin, MSM
- Dosage: Two capsules everyday
- Price: $69*
Performance Lab Flex Pros & Cons
Pros
- This product may reduce joint inflammation
- It is suitable for vegans
- It doesn’t contain soy or tree nuts
- The ingredients are all natural
Cons
- The results may vary from one user to other
- The product reviews are limited
Instaflex Advanced – Best Joint Support Supplement
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*All the prices listed here are as they appear on their websites and are subject to change.
Our Rating
Instaflex Advanced promises advanced joint support, containing UC-II collagen as its star ingredient. With carefully-resourced ingredients and clinically proven research, Instaflex Advanced can be used to fight joint disease.
Key Specs
- Form: Capsules
- Type: Supplements
- Benefit: Promotes joint health, provides joint relief, supports joint health, flexibility, and mobility
- Brand: Instaflex Advanced
- Active Ingredients: Turmeric Extract, Resveratrol, AprèsFlex®-Boswellia serrata Extract, Hyaluronic Acid, Bioperine®-Black Pepper Extract (fruit)
- Dosage: Take 1 capsule daily
- Price: $69.99* + Shipping
Instaflex Pros & Cons
Pros
- Improves joint mobility and flexibility; improved joint health for an active lifestyle
- Fast and effective for pain relief
- Natural extracts – turmeric, resveratrol – anti-inflammatory and antioxidant properties to reduce joint damage
Cons
- Cannot be taken by pregnant or nursing women
- Not recommended for those allergic to salicylates
- May interact with other prescribed medications
- Not recommended for those with gastric problems
Jocko Joint Warfare – Best Supplement For Joint Mobility
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*All the prices listed here are as they appear on their websites and are subject to change.
Our Rating
Jocko Joint Warfare supplement is a combination of anti-inflammatory and joint support compounds that claims to alleviate joint pain, reduce inflammation, promote joint mobility, fight age, enhance joint flexibility, and maintain overall joint health.
Key Specs
- Form: Capsules
- Type: Supplement
- Benefit: Helps alleviate joint pain, promotes joint mobility and flexibility, joint protection
- Brand: Origin
- Active Ingredients: Glucosamine, Methylsulfonylmethane, Boswellia, Sea Cucumber, Turmeric
- Dosage: 3 capsules one time daily
- Price: $69.00*
Jocko Joint Warfare Pros & Cons
Pros
- The product claims to be formulated with natural ingredients
- It may reduce inflammation of the joint tissues
- The supplement could support mobility and flexibility
Cons
- It contains shellfish (shrimp and crab)
- The supplement is not a replacement for treatment
- Pain may recur after dose completion
- It may not provide fast joint pain relief
Omega XL – Best Fish Oil Supplement For Joint Pain
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*All the prices listed here are as they appear on their websites and are subject to change.
Our Rating
Omega XL is another joint pain supplement that contains an extract derived from green-lipped mussel. The mussels are sourced directly from New Zealand, using sustainable practices and are a rich source of omega-3 fatty acids.
Key Specs
- Form: SoftGel Capsules
- Type: Supplements
- Benefit: Supports joint and bone health, improves mobility, and enhances muscle recovery
- Phone & Address: 1-800-488-8082; 4150 SW 28th Way Fort Lauderdale, FL 33312; [email protected]
- Brand: Great HealthWorks
- Active Ingredients: Flaxseed Oil, Omega 3, Vitamin E, Green Lipped Mussel Oil, and Olive Oil
- Dosage: Take 4 gel capsules daily
- Price: $39.95*
Omega XL Pros & Cons
Pros
- Natural relief from joint pain and inflammation
- Safe and effective
- Additional beneficial ingredients – olive oil, vitamin E
- Improves joint mobility, flexibility, and strength
- Easy to swallow soft gel caps with no fishy aftertaste
- Money back guarantee.
Cons
- Contains shellfish (for those with allergies)
- The exact amount of each ingredient is unknown
- More expensive than other muscle and joint pain supplements
- No information on clinical trials
Osteo Bi-Flex – Best Supplement For Osteoarthritis
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*All the prices listed here are as they appear on their websites and are subject to change.
Our Rating
Osteo Bi-Flex is a joint supplement which works to solve some of the most common complaints associated with arthritis. It contains key ingredients such as glucosamine and chondroitin, as well as natural extracts like Boswellia.
Key Specs
- Form: Capsules
- Type: Supplements
- Benefit: Protects joint, support joint mobility, improves joint comfort
- Phone & Address: 1-888-VITAHELP (848-2435)
- Brand: Osteo Bi-Flex
- Active Ingredients: Glucosamine, Vitamin C, Manganese, Joint Shield™ 5-Loxin Advanced
- Dosage: Take 2 tablets per day, preferably with food
- Price: $13.29*
Osteo Bi-Flex Pros & Cons
Pros
- Reduces joint pain and stiffness and supports long-term joint health
- Potential to reduce further cartilage breakdown
- Claims to make a difference in 7 days
- Reputable company
Cons
- Hard to swallow, due to the large size of the tablets
Aleve – Best Supplements For Arthritis Pain
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*All the prices listed here are as they appear on their websites and are subject to change.
Our Rating
Aleve is an over-the-counter non-steroidal anti-inflammatory drug, recommended for arthritis pain. It is also commonly used for headaches and backaches.
Key Specs
- Form: Capsules
- Type: Supplements
- Benefit: Works on minor aches and pains due to minor arthritis, back and muscle aches, and headache
- Phone & Address: 800-395-0689; Bayer Consumer Health, Attn: Consumer Relations, P.O. Box 811930, Boca Raton, FL 33481-1930
- Brand: Aleve
- Active Ingredients: Naproxen Sodium
- Dosage: Take 2 gelcaps
- Price: $13.29*
Aleve Pros & Cons
Pros
- Easy to open arthritis cap – beneficial for those who have hand arthritis
- Active ingredient – naproxen sodium – temporary relief from joint pain
- Strength lasts up to 12 hours, only two pills per day
- May also bring down the fever
- Temporarily blocks the production of prostaglandins, which are responsible for pain sensation
Cons
- May interact with prescribed medications
- Cannot be taken by those who suffer from cardiovascular disease (risk of thrombotic events), peptic ulcer or gastrointestinal bleeding, or liver disease
CAUTION: “Do not take more than the suggested dosage under any circumstances.”
Natural Ingredients, Herbs, Medications, Supplements, and Vitamins To Help With Joint Pain
There are tons of supplements for inflammation and joint pain that claim to treat joint pain, but which ones actually work? Here’s a look at 8 of the best supplements for joints, and what the existing research says about them.
Glucosamine
A natural substance found in cartilage and fluid between joints. Glucosamine is necessary for the synthesis of glycosaminoglycan, which contributes to both the constitution and the actual repair of joint cartilage. It is commonly harvested from shellfish, but there are also artificial versions made in the laboratory.
There are a few different forms of glucosamine used in best joint pain relief supplements and there is conflicting research about the effectiveness of them in treating joint pain. Is Glucosamine good for joint pain? According to the Mayo Clinic and Medline Plus, Glucosamine sulfate appears to show the most promise in reducing pain for those with osteoarthritis and may slow the deterioration of joints.[2][3]
On the other hand, the Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) found glucosamine HCl combined with chondroitin sulfate to significantly improve pain in those with moderate to severe joint pain.[4]
Chondroitin
A substance naturally found in cartilage and in supplement form is from animal sources like cows, pigs, or sharks. This ingredient has excellent anti-inflammatory properties.
Chondroitin significantly reduced joint pain and the narrowing of joint space, as well as improved overall physical function in those with osteoarthritis, as discussed in this study.[5]
MSM
A natural sulfur-based chemical found in the body and several types of plants necessary for the formation and repair of connective tissue.
This study discusses how MSM can reduce joint pain and inflammation, enhance joint mobility and range of motion, potentially preserve joint cartilage, and even improve post-exercise muscle soreness.[6]
S-adenosyl-L-methionine (SAMe)
SAMe is produced by the liver from an amino acid, methionine, and is commonly added to joint pain relief supplement to reduce pain, and inflammation, and improve overall physical function.
One study found this substance alone to be just as effective in managing osteoarthritis in the knee as Celebrex, a common anti-inflammatory drug.[7]
Turmeric
A popular spice in the Indian cuisine that is believed to have a multitude of beneficial properties. Turmeric has antioxidant and anti-inflammatory properties due to its active compound, curcumin.[8]
This spice has been found to treat symptoms of arthritis just as well as ibuprofen and may be beneficial in the treatment of diabetes, colitis, and various cancers.
Turmeric is also commonly used in both Chinese and Indian medicine to modify the response of the immune system and prevent further joint inflammation caused by arthritis.
Boswellia
Also known as Indian frankincense, Boswellia is appreciated for its ancient anti-inflammatory and analgesic properties commonly used in Ayurveda medicine.
Several studies have found Boswellia to relieve pain in patients who suffer from osteoarthritis or rheumatoid arthritis.
This study also mentions Boswellia’s potential in reducing the degradation of glycosaminoglycan, preventing further loss of cartilage.[9]
Devil’s Claw (harpagophytum)
An herb commonly used in South Africa that is well known for its pain-relieving and anti-inflammatory effects mainly due to its active compound, harpagoside.
It may be effective in providing natural joint pain relief in those with osteoarthritis, minimally reducing the need for anti-inflammatory drugs.
Fish oil
The supplements rich in omega-3 fatty acids play a role in the structure of cells, provide useful energy, and are popularly known for their anti-inflammatory properties.
DHA and EPA can treat different types of arthritis, but have been found to significantly reduce joint stiffness and tenderness specifically in those with rheumatoid arthritis, according to the Arthritis Foundation.[10]
There are several omega-3 fatty acids, but the most researched are docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), which are highest in salmon.[11]
Tips for Choosing the Best Joint Supplement For You
Choosing supplements for joint pain and stiffness can be a difficult task, especially since there are several brands with various ingredient combinations and dosages. The first thing to do before starting any supplement is to discuss it with your healthcare provider to ensure the supplement will not interfere with any pre-existing health conditions or any medications you are taking.
Start by looking into common supplement brands and reviewing the labels. Check to see if the supplement contains important joint-protective active ingredients. It is also important to look at the additional ingredients – typically, the longer the “additional” ingredient list is, the more additives and fillers there are.
It would be great if natural supplements for arthritis could be approved by the Food and Drug Administration (FDA), but the FDA “does not have the authority to review dietary supplement products for safety and effectiveness before they are marketed.”
Each company is responsible for ensuring their joint pain pills are safe before selling them. Several companies will have their supplements tested by a third-party laboratory for purity and accurate dosages for safety and reputability. Companies will mention additional testing on their website and/or on their supplement bottles.
It is also beneficial to look into the company itself, see if they are rated by the Better Business Bureau, and read up on as many consumer reviews as possible. Reviews can offer valuable information such as specific pros/cons of taking the supplement, potential side effects, and various timeframes for noticeable benefits.
Lastly, do not get stuck on price. Strive to purchase a supplement from a reputable company. Higher-quality supplements that help joint pain will generally be more expensive, but not always. You are usually paying a higher price for the purity of active ingredients and a shortlist of additional filler ingredients.
Alternative Therapies For Arthritis and Joint Pain
Now that you’re aware of some of the best joint pain supplements on the market, here are some alternative therapies for arthritis that you could also consider.
Topical Creams and Gels – These creams are meant to be massaged into your skin. They contain ingredients like capsaicin which stimulate nerve endings, helping to block pain receptors. Australian Dream, Biofreeze, Aspercreme, and Penetrex Cream are the few brands to consider for joint pain relief.
Physical Therapy – A physical therapist can help you with body movement and correct positioning, which can ease your symptoms. They can also provide you with equipment to help you like braces and splints.
Electrical Stimulation – This involves placing electrodes on the part of your body that’s in pain and delivering electrical stimulation.
Acupuncture – These small needles placed in your body at various points can improve your blood flow and stimulate nerves, muscles, and connective tissue. This can stimulate natural painkillers in the body.
Massage – Massage is a good solution, but not when you are actively in terrible pain. Otherwise, the manipulation of your muscles may lessen the pain and swelling associated with arthritis.
When to See a Doctor
The rule of thumb is that if your joint pain and swelling last more than 2 weeks, you should go see a doctor. Of course, if the pain is really bad you may want to make an appointment before that. There’s a good chance that your physician will refer you to a specialist like a rheumatologist. This is a doctor who focuses specifically on arthritis and other joint conditions.
The Final Verdict
Natural supplements for joint pain are meant to help improve the health of joints, reduce pain, and enhance mobility to continue living an active lifestyle. All of the joint pain supplements mentioned above contain active ingredients beneficial for typical aches and pains with the potential to preserve cartilage and slow down the progression of joint degeneration.
Do not hesitate to try a variety of joint pain supplements that work and which are best for you. Everyone’s body is different and has different needs, which is why there are so many joint relief products available.
When trying a new and one of the best joint supplements for knees, it may be a good idea to keep a diary of how you feel each day and any differences you notice in order to eliminate supplements that either do not work for you or cause negative side effects.
Unfortunately, arthritis is a progressive condition and drastically affects the overall quality of life. With the help of joint pain supplements online, you may find some relief from your symptoms. Choose the best and most natural supplement for joints Glucosamine, Chondroitin, Boswellia, and MSM for Joint Health.
Frequently Asked Questions
Q: What are the side effects of Joint Pain Supplements?
A: The potential side effects of supplements for joint pain are determined by the ingredients they contain and dosages used. Many people experience temporary gastric discomfort, nausea, vomiting, diarrhea, heartburn, and abdominal pain. It is important to read the label of the joint pain supplement before taking it.
To explore the potential risk factors associated with these joint supplements, we interviewed Dr. Christopher Liu, Pain Specialist & Anesthesiologist. he explained that these supplements sometimes cause additional side effects for patients with asthma (risk of exacerbation), glaucoma (worsen eye pressure), and shellfish allergy (risk of allergic reaction as glucosamine comes from shellfish). They should also be used with caution in patients who are on certain medications, like warfarin, due to drug interactions.
Q: What is the recommended dosage?
A: These are some of the recommended dosages for ingredients contained in natural supplements for joint pain:
- Glucosamine sulfate – 1500 mg per day
- Chondroitin sulfate – between 800 and 1200 mg per day
- MSM – 1500 mg per day
- Same – between 600 and 1200 mg per day
- Boswellia – between 900 and 1200 mg per day
- Fish oil – 1000 mg per day
Note: your doctor or pharmacist may recommend specific dosages for joint pain. Do not exceed those recommended dosages.
Q: Do Joint Pain Supplements work?
A: The answer is yes, BUT they may not work well for everyone. Although joint pain relief products contain active ingredients that reduce joint pain and support overall joint health, not all joint-related issues or diseases can be managed by supplements alone.
Patience and consistency are also key. Most supplements for joint pain relief will take time to work and will only work if taken on a regular basis.
Note:*Results may vary from person to person and cannot be guaranteed.
Q: What vitamins stop joint pain?
A: Vitamins C, D, and B vitamins are all important for joint health as they help lower inflammation and boost the immune system. Vitamin C plays a role in repairing connective tissues that provide flexibility and support to joints.
Vitamins D and B vitamins help produce hormones and regulate metabolic processes that support joint function. Making sure to get adequate amounts of these key vitamins through diet or supplements can aid the body’s natural pain relief processes.
Q: Who should buy the supplements for arthritis and joint health supplements?
A: Supplements for joint pain are generally recommended for those who have had joint/ligament types of surgeries, those beginning to exhibit the first signs of arthritis, and overall for the older population due to normal wear and tear on joints with age.
Joint supplements may also be taken for preventative measures to support the already healthy functioning of joints and potentially delay the aging process and painful symptoms related to joint degeneration.
Q: Can Vitamin Supplements cause joint pain?
A: Generally speaking, some vitamins for joints will help ease joint pain and improve general health. There’s no evidence to show that they actually cause joint symptoms. However, there is a possibility that an overdose of multivitamins can lead to bone or muscle pain, or muscle weakness.
Q: What are the Best Supplements For Joint Pain that can be taken?
A: This article has suggested joint health supplements you can consider for treating your joint pain. Read the descriptions carefully and make sure you’ve selected the right product for you. Look at the ingredients, side effects, manufacturer, and price, and read the reviews on the products you like best.
In addition, consider other products such as MoveMD , Joint N-11, Nucific Move 360 and do a joint pain relief supplement comparison like Instaflex Joint Support vs. MoveMD and GNC TriFlex vs. Heal-n-Soothe, or turmeric vs glucosamine supplements.
Q: Can you buy Joint Pain Supplements at local or online stores?
A: Yes, there are many of these products available at online stores, like joint pain supplements on Amazon and joint pain supplements GNC. There are also a number of brands which are sold in offline stores like Walmart joint pain supplements or joint pain supplements Costco.
Q: Should you give glucosamine and chondroitin gummies a try?
A: Glucosamine and chondroitin are substances which exist naturally in the connective tissue, and they are very effective at healing joint tissue and helping to lessen arthritis symptoms. This is especially true if they occur together.
If you are considering taking a supplement, there are some health warnings you have to note. For example, glucosamine comes from seafood, so if you have an allergy you should avoid joint pain supplements. Glucosamine for joint pain is not suitable for people with diabetes, asthma, glaucoma, high cholesterol, and high blood pressure.
Chondroitin is not suitable for people with asthma, blood clotting disorders, or prostate cancer.
Sources
Health Insiders relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.
[1] Arthritishttps://www.ncbi.nlm.nih.gov/books/NBK518992/
[2] Glucosamine. https://www.mayoclinic.org/drugs-supplements-glucosamine/art-20362874
[3] Glucosaminehttps://medlineplus.gov/druginfo/natural/807.html
[4] Glucosamine and chondroitin for osteoarthritis pain. Arthritis Foundation. https://www.arthritis.org/health-wellness/treatment/complementary-therapies/supplements-and-vitamins/glucosamine-chondroitin-osteoarthritis-pain
[5] Henrotin Y, Mathy M, Sanchez C, Lambert C. Chondroitin sulfate in the treatment of osteoarthritis: from in vitro studies to clinical recommendations. Ther Adv Musculoskelet Dis. 2010 Dec;2(6):335-48. doi: 10.1177/1759720X10383076. PMID: 22870459; PMCID: PMC3383492
[6] Butawan M, Benjamin RL, Bloomer RJ. Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement. Nutrients. 2017 Mar 16;9(3):290. doi: 10.3390/nu9030290. PMID: 28300758; PMCID: PMC5372953
[7] Sharma A, Gerbarg P, Bottiglieri T, Massoumi L, Carpenter LL, Lavretsky H, Muskin PR, Brown RP, Mischoulon D; as Work Group of the American Psychiatric Association Council on Research. S-Adenosylmethionine (SAMe) for Neuropsychiatric Disorders: A Clinician-Oriented Review of Research. J Clin Psychiatry. 2017 Jun;78(6):e656-e667. doi: 10.4088/JCP.16r11113. PMID: 28682528; PMCID: PMC5501081
[8] Daily JW, Yang M, Park S. Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. J Med Food. 2016 Aug;19(8):717-29. doi: 10.1089/jmf.2016.3705. PMID: 27533649; PMCID: PMC5003001.
[9] Siddiqui MZ. Boswellia serrata, a potential antiinflammatory agent: an overview. Indian J Pharm Sci. 2011 May;73(3):255-61. doi: 10.4103/0250-474X.93507. PMID: 22457547; PMCID: PMC3309643.
[10] Omega-3 Fatty Acids for Your Health: https://www.arthritis.org/health-wellness/treatment/complementary-therapies/supplements-and-vitamins/omega-3-fatty-acids-for-health
[11] Omega-3 Fatty Acids https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/
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The Health Insiders Team takes pride in bringing you the latest in nutritional research, skincare, healthy living, and wellness hacks. [Read Full Bio]
Brittany Ferri, MS, OTRL, CLT
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